Interaction between CETP polymorphism and dietary insulin index and load in relation to cardiovascular risk factors in diabetic adults

Abstract Gene–diet interactions may play an important role in the inter individual diversity observed on cardiovascular disease (CVD) risk factors. Therefore, current study, we examined interaction of CETP TaqB1 polymorphism with dietary insulin index and load (DII DIL), altering CVD factors among type 2 diabetes mellitus (T2DM). In this cross-sectional blood samples were collected from 220 diabetic patients (134 females 86 male) a mean age 52.24 years Tehran, Iran. DIL DII obtained via validated food-frequency questionnaire (FFQ). Taq1B was genotyped by polymerase chain reaction-restriction fragment length (PCR-RFLP) method. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), antioxidant capacity (TAC), pentraxin-3 (PTX3), isoprostaneF2α (PGF2α). interleukin 18 (IL18), leptin ghrelin measured standard protocol. Patients B1B1 genotype had lower lipid profiles include LDL/HDL (P < 0.001) TG = 0.04) when they consumed diets higher index. Moreover, carriers B2B2 who last tertile inflammatory SOD 0.01), PGF2α CRP 0.02). Further, significant between shown terms WC where highest following score. However, 0.04), TAC 0.02), 0.02) Based it could be proposed that associated T2DM high indices, DIL. It seems can invert result produced insulin. This conclusion illustrates B1 allele counteract induced